Large number of new chemical entities (NCE) present formulation and bioavailability problems because of the dose and poor solubility in solvent and co-solvent systems. There is an increasing interest to expand the range of targetable lipid based systems to solubilize a wide variety of drugs, to improve stability, ease of processing and manufacture in a sterile form. New class of parenteral lipid based drug delivery system includes tocol emulsions, solid lipid nanoparticles and nanosuspensions, sterically stabilized phospholipid micelles, lipid microbubbles and lipoprotein drug carriers. This review article covers the challenges faced by the formulation scientist at each stage of product development of lipid based drug delivery system.
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